The e-ROSA project seeks to build a shared vision of a future sustainable e-infrastructure for research and education in agriculture in order to promote Open Science in this field and as such contribute to addressing related societal challenges. In order to achieve this goal, e-ROSA’s first objective is to bring together the relevant scientific communities and stakeholders and engage them in the process of coelaboration of an ambitious, practical roadmap that provides the basis for the design and implementation of such an e-infrastructure in the years to come.
This website highlights the results of a bibliometric analysis conducted at a global scale in order to identify key scientists and associated research performing organisations (e.g. public research institutes, universities, Research & Development departments of private companies) that work in the field of agricultural data sources and services. If you have any comment or feedback on the bibliometric study, please use the online form.
You can access and play with the graphs:
- Evolution of the number of publications between 2005 and 2015
- Map of most publishing countries between 2005 and 2015
- Network of country collaborations
- Network of institutional collaborations (+10 publications)
- Network of keywords relating to data - Link
EPIGENETIC REGULATION IN BOVINE CELLS: NUTRIENT-INDUCED MODULATION OF GENE EXPRESSION AND CELLULAR FUNCTIONS
Research on epigenetics and nutrigenetics, the genome-nutrient interface and is in its infancy with respect to livestock species. Ruminant species have evolved to metabolize short-chain fatty acids (VFA) to fulfill up to 70% of their energy requirements. Our studies revealed that VFA, especially butyrate, participate in metabolism as nutrients and as inhibitors of histone deacetylases (HDAC), which are one of the most important types of epigenetic regulators. The detailed mechanisms by which butyrate induces cell growth arrest and apoptosis were analyzed using global gene expression profiles and the Ingenuity Pathways Knowledge Base. Gene expression profiling with high-density oligonucleotide microarrays indicated that butyrate induces many significant changes in the expression of genes associated with many regulatory pathways that are critical to cell growth, immune response and signal transduction. The functional category and pathway analyses of the microarray data revealed that several canonical pathways (Cell cycle: G2/M DNA damage checkpoint; pyrimidine metabolism; Cell cycle: G1/S Checkpoint Regulation; and purine metabolism; insulin-like growth factor axis components) were significantly affected. Butyrate Induced cell cycle arrest in bovine cells through targeting gene expression relevant to DNA replication apparatus. Our results also suggest that IGF2, not IGF1, along with its receptor (IGF2R) played a critical role in regulating cell cycle progression and programmed cell death. The present findings provide an example of epigenetic regulation of genome at work and basis for understanding the full range of the biological roles and the molecular mechanisms that butyrate may play in human and animal cell growth, proliferation, and energy metabolism.
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