e-infrastructure Roadmap for Open Science in Agriculture

A bibliometric study

The e-ROSA project seeks to build a shared vision of a future sustainable e-infrastructure for research and education in agriculture in order to promote Open Science in this field and as such contribute to addressing related societal challenges. In order to achieve this goal, e-ROSA’s first objective is to bring together the relevant scientific communities and stakeholders and engage them in the process of coelaboration of an ambitious, practical roadmap that provides the basis for the design and implementation of such an e-infrastructure in the years to come.

This website highlights the results of a bibliometric analysis conducted at a global scale in order to identify key scientists and associated research performing organisations (e.g. public research institutes, universities, Research & Development departments of private companies) that work in the field of agricultural data sources and services. If you have any comment or feedback on the bibliometric study, please use the online form.

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Preliminary association of microsatellite heterozygosity with footrot in domestic sheep


Genetic heterozygosity in wild, unmanaged animal populations is often associated with protection against infectious disease. However, little is known about the relationship between heterozygosity and disease susceptibility in domesticated livestock, where disease resistance has the potential to improve animal welfare and productivity. We have investigated whether susceptibility to footrot, an important cause of poor welfare and reduced productivity in sheep, is associated with heterozygosity at 14 candidate microsatellite loci. Heterozygosity at locus BMC5221 was associated with resistance to footrot (P = 0.0034). This locus was selected based on a gene ontology classification of 'response to Gram-negative bacteria'. Sheep homozygous at BMC5221 were at increased risk of virulent footrot (OR = 4.8, 95% CI = 1.5-15.3), with a dose response relationship between homozygosity and disease severity. A highly significant homozygote deficit was observed in sheep without virulent footrot (observed = 4, expected = 21, chi(2) = 13.76, P = 0.0002) but not in sheep that had clinical disease, suggesting homozygotes were disproportionately likely to contract virulent footrot. Our results indicate that genetic heterozygosity might be important for healthy immune function in domesticated livestock. The use of gene ontology codes might prove a useful strategy to target selection of candidate markers in future studies. (C) 2011 Elsevier B.V. All rights reserved.

  • GB
  • DE
  • Univ_Warwick (UK)
  • Univ_Cambridge (UK)
  • Bielefeld_Univ (DE)
Data keywords
  • ontology
Agriculture keywords
  • livestock
Data topic
  • information systems
  • modeling
  • semantics
Document type

Inappropriate format for Document type, expected simple value but got array, please use list format

Institutions 10 co-publis
  • Univ_Cambridge (UK)
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e-ROSA - e-infrastructure Roadmap for Open Science in Agriculture has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 730988.
Disclaimer: The sole responsibility of the material published in this website lies with the authors. The European Union is not responsible for any use that may be made of the information contained therein.