e-infrastructure Roadmap for Open Science in Agriculture

A bibliometric study

The e-ROSA project seeks to build a shared vision of a future sustainable e-infrastructure for research and education in agriculture in order to promote Open Science in this field and as such contribute to addressing related societal challenges. In order to achieve this goal, e-ROSA’s first objective is to bring together the relevant scientific communities and stakeholders and engage them in the process of coelaboration of an ambitious, practical roadmap that provides the basis for the design and implementation of such an e-infrastructure in the years to come.

This website highlights the results of a bibliometric analysis conducted at a global scale in order to identify key scientists and associated research performing organisations (e.g. public research institutes, universities, Research & Development departments of private companies) that work in the field of agricultural data sources and services. If you have any comment or feedback on the bibliometric study, please use the online form.

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Differences in the transcriptional responses induced by Theileria annulata infection in bovine monocytes derived from resistant and susceptible cattle breeds


Tropical theileriosis is a cattle disease of global economic importance, caused by the tick-borne protozoan parasite Theileria annulata. Conventional control strategies are failing to contain the disease and an attractive alternative is the use of pre-existing genetic resistance or tolerance. However, tropical theileriosis tolerant cattle are less productive than some susceptible breeds. Breeding for combined resistance and production traits requires an understanding of the mechanisms involved in resistance. We have compared the transcriptional response of monocytes derived from tolerant (Sahiwals, Bos indicus) and susceptible (Holstein-Friesians, Bos taurus) cattle to in vitro infection with T annulata using our recently developed bovine macrophage-specific cDNA microarray. Over 150 genes exhibited breed-specific differential expression during the course of infection, of which nearly one-third were differentially expressed in resting cells, implying that there are inherent differences between monocytes from the two breeds. Fifty sequences currently match only with expressed sequence tags or are unique to the library used to generate the microarray. The greatest breed differences were observed for Toll-like receptor 10 and signal-regulatory protein alpha (SIRPA). Other differentially expressed genes included MHC class II DQ alpha, CD9 and prion protein (PRNP). The differential expression of 40 genes was validated by RT-PCR and a subset of these was validated by quantitative RT-PCR, e.g. PRNP and SIRPA. A large proportion of the differentially expressed genes encode proteins expressed on the plasma membrane or in the extracellular space and cell adhesion was one of the major Gene Ontology biological processes identified. We therefore hypothesise that the dissimilar susceptibility to tropical theileriosis exhibited by Sahiwal and Holstein-Friesian cattle is due to breed-specific differences in the interaction of infected cells with other immune cells, which influences the immune response generated against T annulata infection. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

  • GB
  • TN
  • BBSRC_Biotech_&_Biol_Sci_Res_Council (UK)
Data keywords
  • ontology
Agriculture keywords
  • cattle
Data topic
  • information systems
  • semantics
Document type

Inappropriate format for Document type, expected simple value but got array, please use list format

Institutions 10 co-publis
  • BBSRC_Biotech_&_Biol_Sci_Res_Council (UK)
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e-ROSA - e-infrastructure Roadmap for Open Science in Agriculture has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 730988.
Disclaimer: The sole responsibility of the material published in this website lies with the authors. The European Union is not responsible for any use that may be made of the information contained therein.